WebNeurotoxicity is an obvious adverse effect in Patients encountering a complete course of chemotherapy. The present work is conducted to evaluate the neuroprotective effect of Ginkgo biloba (Ginkgo) against the neurotoxicity induced by Cisplatin (Cis) in rats. Forty male Wistar albino rats were arranged into four groups: (1) Control group, rats were … WebOct 7, 2024 · Depending on a dose (single or cumulative) cisplatin can cause leucocytopenia, thrombocytopenia, and anemia also in mice (toxicity on hemopoietic cells, Figure 1 ). Myelotoxicity can be observed already a day after cisplatin administration and is more toxic for earlier hemopoietic progenitor cells than for the mature cells [ 74 ].
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WebCisplatin-induced testicular damage is a major obstacle in the application of cisplatin as chemotherapeutic agent. However, it remains as one of the most widel 掌桥科研 一站式科研服务平台 WebNov 19, 2013 · Cisplatin exposure results in intracellular ROS increase in normal cells [21–23] and treatment with antioxidants ameliorates the toxic effects of cisplatin on several organs [24–27], suggesting an involvement of oxidative stress in the pathogenesis of cisplatin-induced dose-limiting toxicities. However, little is known about the mechanism ...
WebIn an attempt to avoid renal toxicity, saline diuresis was induced by administering 0.9% saline solution intravenously at a rate of 20 ml/kg/hr for 4 hours before and 2 hours after cisplatin administration. All four cats became dyspneic … WebMay 2, 2014 · Cisplatin early ototoxic effects cause hearing impairment in the high frequencies at 6 kHz, 8 kHz, and above as measured by conventional or extended high-frequency pure tone audiometry [ 11 ]. Multiple doses of cisplatin worsen hearing, ultimately affecting the speech frequency range (500–4000 Hz).
Commonly reported side effectsof cisplatin include: bone marrow depression, nephrotoxicity, and ototoxicity. Continue reading for a comprehensive list of adverse effects. Applies to cisplatin: intravenous powder for solution, intravenous solution. See more Along with its needed effects, cisplatin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediatelyif any of … See more Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Some side effects may not be reported. You may report them to the FDA. Medical … See more Some side effects of cisplatin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be … See more WebMay 8, 2024 · Cisplatin chemotherapy is used alone or in combination to treat a variety of cancers, including ovarian, testicular, lung, cervical, bladder, head and neck, and gastric cancers as well as lymphoma, melanoma, and more. Although it offers options for many cancer types, its use may result in nephrotoxicity, a dose-limiting side effect.
WebMay 17, 2024 · The underlying mechanisms were mostly attributed to the high cisplatin toxic effect on body weight loss in chemotherapy treatment which may be due to the acceleration of water elimination by urine associated with continuing dehydration (Tikoo, Bhatt, Gaikawad, Sharma, & Kabra, 2007) or the reduction in food ingestion because of …
WebThe major toxicities of a cisplatin overdose include nausea and vomiting, renal insufficiency, electrolyte abnormalities, myelosuppression, ototoxicity, peripheral … cst civil serviceWeb2 days ago · It was discovered that both iodide complexes, 9a and 9b, were more effective than the chloride analogs, 10a and 10b, and cisplatin against all cisplatin-resistant cell lines; while the chloride complexes had an effect comparable to cisplatin: 11 and 11.9 μM vs. 4 μM in the A2780 cell line; 21 and 19 μM vs. 22 μM in the A2780cisR cell line ... cst cleaningWebOct 5, 2014 · Cisplatin treatment has been associated with several toxic side effects including nephrotoxicity (de Jongh, van Veen et al., 2003), hepatotoxicity and Cardiotoxicity (Al-Majed, 2007). Many cardiac events have been reported in many case reports including electro-cardiographicchanges, arrhythmias, myocarditis, cardiomyopathy and congestive … early education academy abington maWebApr 11, 2024 · It suggests that toxic side effects of cisplatin can be reduced in combination therapy. Another example of combination therapy is with melatonin which is an indolamine molecule produced by pineal gland and other organs. Its main function is to control circadian rhythms and to treat insomnia. cs.tcldh.comWebSep 1, 2024 · Acute overdosage with Cisplatin for injection may result in renal failure, hepatic failure, hearing loss, ocular toxicity, myelosuppression, nausea and vomiting, … cst classic allroundWebAdverse effects of RT-CT were grades 3 to 4 neutropenia (four patients) and grade 3 esophageal toxicity (one patient). No treatment-related deaths occurred. Conclusion: The oral vinorelbine-cisplatin combination with concurrent RT is feasible and has a favorable risk-benefit ratio in stage IIIA/IIIB NSCLC. cst civil trainingWebSep 3, 1991 · After a preliminary dose-finding study involving 12 patients with advanced or locally recurrent head and neck cancer, 27 patients were treated on a phase II protocol, using fluorouracil 350 mg/m2/d by continuous intravenous (IV) infusion over 5 days, followed on the sixth day by a 2-hour IV infusion of cisplatin 50 mg/m2, administered during the … cst clear history