Cullin family protein binding

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August undefined, 2024

WebCullin 1, also known as CUL1, is a human protein and gene from cullin family. This protein plays an important role in protein degradation and protein ubiquitination . WebWerner helicase interacting protein 1 (WRNIP1) is a ubiquitin-binding protein that undergoes extensive post-translational modification including ubiquitination, sumoylation, …

Q13617 - UniProt

WebCullin RING ubiquitin E3 ligases (CRL) is the largest family of ubiquitin E3 ligases. In fact, CRL is a multiprotein complex, in which cullin serves as a scaffold linking a ubiquitin … WebMar 21, 2024 · Enables cullin family protein binding activity. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; regulation of protein neddylation; and response to UV-C. Located in nucleus; perinuclear region of cytoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2024] fitchat corteva

123879 - Gene ResultDCUN1D3 defective in cullin neddylation 1 …

WebNational Center for Biotechnology Information WebApr 27, 2024 · The Cullin-RING ligases (CRL), encompassing Cullin family proteins as scaffold components, are the largest class of RING-type E3 ubiquitin ligases that mediate polyubiquitination of... WebMay 2, 2016 · We identified that several putative miRNA target genes like Cullin 2 (CUL2), member RAS oncogene family (RAB6A), UBE2I, clathrin heavy chain 1 (CLTC), Desmocollin 3 (DSC3), Ras Family Small GTP Binding Protein (RAP1B), LSM12 homolog (LSM12), protocadherin 11 X-linked (PCDH11X) and HCLS1 Associated Protein X-1 … fitch athene

CoCUN, a Novel Ubiquitin Binding Domain Identified in N4BP1

The structure and regulation of Cullin 2 based E3 …

WebDec 4, 2024 · Enables cullin family protein binding activity. Involved in positive regulation of protein neddylation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2024] DCUN1D4 defective in cullin neddylation 1 domain containing 4 [ (human)] Web(2008) Identifying determinants of cullin binding specificity among the three functionally different Drosophila melanogaster Roc proteins via domain … fitchat.corteva.comWeb1 day ago · Targeting oncofusion proteins is an attractive approach for cancer treatment. First, fusion proteins are specifically expressed in cancer cells rather than in normal cells. Accordingly, the specific targeting of fusion proteins potentially offers limited toxicity. Furthermore, fusion proteins may be the sole driver of some cancers, making them ... can goodcook go in the dishwasher

"WebMar 21, 2024 · Summary. Enables cullin family protein binding activity. Involved in positive regulation of protein neddylation and regulation of protein ubiquitination. … " - Cullin family protein binding

Cullin family protein binding

IJMS Free Full-Text Cullin 3 Exon 9 Deletion in Familial ...

WebMay 3, 2024 · We also narrowed down the Cullin family members with the presence of both Cullin and Cullin_Nedd8 domains ... McLoughlin, F.; Vierstra, R.D. Atg8-binding uim proteins define a new class of autophagy adaptors and receptors. Cell 2024, 177, 766–781.e24. [Google Scholar] Marshall, R.S.; McLoughlin, F.; Vierstra, R.D. Autophagic … WebMar 21, 2024 · Enables cullin family protein binding activity. Involved in cellular response to DNA damage stimulus; positive regulation of protein neddylation; and regulation of cell growth. Located in nucleus and spindle. [provided by Alliance of Genome Resources, Apr 2024] GeneCards Summary for DCUN1D5 Gene

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WebThe evolutionarily conserved cullin family proteins can assemble as many as 400 distinct E3 ubiquitin ligase complexes that regulate diverse cellular pathways. CUL4, one of three founding cullins conserved from yeast to humans, uses a large beta-propeller protein, DDB1, as a linker to interact with … CRL4s: the CUL4-RING E3 ubiquitin ligases WebIts expression is induced by heat shock. HSP47 is expressed in the endoplasmic reticulum. These cells synthesize and secrete type I and type II collagen. [7] The protein localizes to the endoplasmic reticulum lumen and binds collagen; thus it is thought to be a molecular chaperone involved in the maturation of collagen molecules.

WebGene ID: 31014, updated on 24-Nov-2024 Summary Enables cullin family protein binding activity and ubiquitin protein ligase activity. Involved in several processes, including negative regulation of signal transduction; positive regulation of neuron remodeling; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. WebNov 6, 2024 · Gene ID: 84259, updated on 6-Nov-2024 Summary Enables cullin family protein binding activity. Involved in cellular response to DNA damage stimulus; positive regulation of protein neddylation; and regulation of cell growth. Located in nucleus and spindle. [provided by Alliance of Genome Resources, Apr 2024] Other designations

WebNov 28, 2024 · Recently, a novel ubiquitin-binding domain was identified at the C-terminal end of KHNYN (also called KIAA0323) protein. This domain, called CUBAN for cullin binding domain associating with NEDD8, shows a clear preference for monomeric NEDD8 and mediates the interaction of KHNYN with neddylated cullins [10,11]. Although the … Webprotein binding cullin family protein binding (GO:0097602) is_a protein binding dynein heavy chain binding (GO:0045504) is_a protein binding modification-dependent protein binding (GO:0140030) is_a protein binding growth factor binding (GO:0019838) is_a protein binding

WebGene ID: 83962, updated on 6-Nov-2024 Summary Predicted to enable cullin family protein binding activity and identical protein binding activity. Predicted to be involved in neurogenesis. Predicted to act upstream of or within cell differentiation and muscle organ development. Located in P-body.

WebHere we identify Skp2 as a component of an Skp1-cullin-F-box complex that is based on a Cul1-Ro52 RING finger B-box coiled-coil motif family protein catalytic core. Ro52-containing complexes display E3 ligase activity and promote the ubiquitination of Thr187-phosphorylated p27 in a RING-dependent manner in vitro. can good brake pads helpWebDec 4, 2011 · Cullin proteins are molecular scaffolds that have crucial roles in the post-translational modification of cellular proteins involving ubiquitin. The mammalian cullin … fitch at-maniaWebCullin 3 (CUL3) is the scaffold of Cullin3 Ring E3-ligases (CRL3s), which use various BTB-adaptor proteins to ubiquitinate numerous substrates targeting their proteasomal … fitch athoraWebDec 8, 2024 · Summary Predicted to enable cullin family protein binding activity and ubiquitin-ubiquitin ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in positive regulation of mitotic metaphase/anaphase transition; protein K11-linked ubiquitination; and ubiquitin-dependent protein catabolic … can good china go in dishwasherWebProduct Characteristics: The DCN1-like protein family is comprised of Dcun1D1, Dcun1D2, Dcun1D3, Dcun1D4 and Dcun1D5. The founding member, Dcun1D1, is involved in the … can good cholesterol outweigh the badWebOct 31, 2024 · Cullin (CUL) proteins have critical roles in development and cancer, however few studies on CUL7 have been reported due to its characteristic molecular … can good donateWebNov 24, 2024 · Predicted to enable cullin family protein binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human SKP1 (S-phase kinase associated protein 1). [provided … can goodenough make great divorce