WebFeb 10, 2024 · Blocking the IL-17A pathway reversed the effects of IL-17A on the IFN-α-induced activation of ISGF3 and anti-HBV efficacy. Conclusions. Our results demonstrate that IL-17A pretreatment could attenuate IFN-α-induced anti-HBV activity by upregulating negative regulators of the critical transcriptional ISGF3 complex. WebJun 26, 2024 · Type I interferon (IFN-I) is induced during innate immune response and is required for initiating antiviral activity, growth inhibition, and immunomodulation. STAT1, STAT2, and STAT3 are activated in response to IFN-I stimulation. STAT1, STAT2, and IRF9 form ISGF3 complex which transactivates downstream IFN-stimulated genes and …
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WebDec 23, 2013 · The interferon-stimulated gene factor 3 (ISGF3) complex (which is composed of STAT1, STAT2 and IFN-regulatory factor 9 (IRF9)) binds to IFN-stimulated response element (ISRE) sequences to activate ... WebMay 28, 2024 · In 1989, Levy et al. provided evidence that the active ISGF3 complex is already detectable within 2 min after exposure of cells to IFNα . Thus, the rapid ISGF3 assembly serves fast and robust IFNα responses that are diminished in time and coincide with the phosphorylation profiles of STAT1 and STAT2 . In this process, important … christina johanning
A molecular switch from STAT2-IRF9 to ISGF3 underlies
WebPhosphorylated Stat1 and Stat2 associate with p48/IRF9 to form a multimeric ISGF3 complex that plays an essential role in the induction of ISG expression (Fu et al. 1990; Darnell et al. 1994). Defective JAK-STAT signaling was found to cause either sensitivity or resistance to IFN, confirming its absolute requirement for adequate response to ... WebDec 23, 2013 · The interferon-stimulated gene factor 3 (ISGF3) complex (which is composed of STAT1, STAT2 and IFN-regulatory factor 9 (IRF9)) binds to IFN-stimulated response … WebOct 27, 2024 · IMPORTANCE Type I IFN signaling in mammalian cells induces formation of the ISGF3 transcription factor complex, which binds to interferon stimulated response … christina jochmann