Klf4 induction

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August undefined, 2024

WebSep 2, 2010 · KLF4 expression seems to be important for maintenance of B-cell quiescence, and KLF4 was shown to be down-regulated on B-cell activation. 9 Remarkably, inhibition of B-cell proliferation by FOXO transcription factors is associated with KLF4 induction. 10 Nevertheless, the effect of KLF4 in B-cell proliferation is probably complex. A complete ... WebNov 12, 2024 · Klf4 pluripotency Introduction The first demonstration that differentiated somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) utilized …

BAALC potentiates oncogenic ERK pathway through interactions …

WebKlf4. Klf4 encodes Krueppel-like factor 4 (Klf4), a zinc finger transcription factor that is evolutionarily conserved from flies to humans. Klf4 is reported to be expressed in the … WebAug 19, 2014 · Induction of KLF4 expression in ovarian cancer cells using lentiviral Tet-on vector. A. Lentiviral Tet-on vector system. Reverse transactivator (rtTA-M3) was driven by human ubiquitin C (UBC promoter), and EGFP or KLF4 was driven by the Dox inducible promoter TRE-tight. To induce the expression of EGFP or KLF4, Dox is required to activate … hello fresh price list

KLF4 Is Essential for Induction of Cellular Identity Change …

WebNov 24, 2024 · For the first set of reprogramming experiments, the TF combination known as OSKM—Oct4, Sox2, Klf4, and c-Myc—was used . However, Oct4 is associated with cervical cancer, Sox2 is highly expressed in melanoma cells, Klf4 and c-Myc are involved in cell proliferation, and c-Myc is also a well-known protooncogene. WebInduction of aberrant DNA methylation is the major pathway by which H. pylori infection induces gastric cancer, and this can be utilized for translational opportunities. ... Krüppel‐like factor 4 (KLF4) has a tumor suppressor role in the progression of gastric cancer (GC), and inhibition or loss of KLF4 expression was identified in GC. ... WebLoss and gain of function experiments demonstrate that the down-regulation of Klf4 expression is required for the induction of EMT in vitro and for metastasis in vivo. In addition, reduced Klf4 expression correlates with shorter disease-free survival of subsets of breast cancer patients. lake reinholdmouth

Rapid induction of Klf4 expression in TM4 cells after …

Krüppel-Like Factor 4 and Its Activator APTO-253 Induce NOXA

WebAug 30, 2007 · KLF4 induces a monocytic phenotype in HL-60 cells To determine whether KLF4 participates directly in monocytic differentiation, we retrovirally infected HL-60 cells with either full-length KLF4 or an empty virus control (EV) and analyzed the cells for various myeloid markers 4 days later. WebApr 18, 2024 · In murine esophageal epithelia, Klf4 overexpression causes chronic inflammation which is mediated by activation of NFκB signaling downstream of KLF4, and this esophageal inflammation produces epithelial hyperplasia and subsequent esophageal squamous cell cancer. lake rehab willoughby ohioWebThere is evidence to suggest that transcription factor KLF4 plays a crucial role in the progression of breast carcinoma, 14 squamous cell carcinoma, 15 lung cancer, 16 and colon cancer. 13 Therefore, KLF4 is a potential diagnostic marker, prognostic factor, or target for novel therapy. To the authors’ knowledge, this is the first study to ... hellofresh price vs grocery store

"WebKLF4 induction could therefore contribute to the induction and progression of the disease by upregulating BMP6. KLF4 can also induce EndMT by binding directly to the promoters of some EndMT markers (Sca1 and Fsp1). Intriguingly, the promoter regions of the EndMT markers that showed a higher binding affinity for KLF4 are surrounded by putative ... " - Klf4 induction

Klf4 induction

The role of KLF transcription factor in the regulation of cancer ...

WebApr 10, 2024 · KLF4 contains an activation domain as well as a repression domain 21 and is therefore able to induce and suppress the transcription of different genes including molecules involved in the... WebMay 5, 2024 · Since its discovery in 1996, KLF4 has been gaining a lot of attention, after it was shown in 2006 as one of four factors required for the induction of pluripotent stem …

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WebFeb 25, 2013 · Klf4 Is a Transcriptional Regulator of Genes Critical for EMT, Including Jnk1 (Mapk8) We have identified the zinc-finger transcription factor Kruppel-like factor 4 (Klf4) … WebAug 28, 2013 · Microarray analysis has shown that many keratin genes were upregulated on KLF4 induction, indicating its role in epithelial differentiation. Additionally, KLF4 has been reported to transactivate promoters of epithelial genes including CYP1A1 , laminin α 3A , laminin 1 , keratin 4 , keratin 19 .

WebKlf4 encodes Krueppel-like factor 4 (Klf4), a zinc finger transcription factor that is evolutionarily conserved from flies to humans. Klf4 is reported to be expressed in the …

WebMar 14, 2016 · KLF4 is upregulated in and required for acinar-to-ductal metaplasia. Klf4 ablation drastically attenuates the formation of pancreatic intraepithelial neoplasia … WebApr 8, 2024 · In p53-mutated TNBC cells, inhibition of KLF4 by RNA interference reduced NOXA expression. Furthermore, treatment of TNBC cells with a KLF4-inducing small compound, APTO-253, resulted in the induction of NOXA expression and …

WebMar 21, 2024 · KLF4 (KLF Transcription Factor 4) is a Protein Coding gene. Diseases associated with KLF4 include Epilepsy, Idiopathic Generalized 15 and Familial Adenomatous Polyposis.Among its related pathways are …

WebJun 2, 2009 · To identify a chemical replacement for Klf4, NL-MEFs were transduced with a subset of reprogramming factors comprising Oct4, Sox2, and c-Myc (OSM). To obtain the … lake renaissance circle wilmington ncWebDec 26, 2024 · The rapid induction of Klf4 expressions by LH was observed in preovulatory GCs. To evaluate whether Klf4 affects GC proliferation and survival, primary rat GCs were isolated from pregnant mare serum gonadotropin-primed Sprague–Dawley rat ovaries and transfected with a Klf4 expression vector or Klf4 -specific siRNA, followed by … hello fresh price per mealWebApr 1, 2004 · We also observed induction of Krüppel-like factor 4 (KLF4), a transcription factor implicated in suppressing cell cycle and antiproliferation activity, partially via p21 induction, and in differentiation of intestinal cells, particularly terminal differentiation of … laker electric \u0026 plumbing incWebJul 19, 2024 · KLF4 is a therapeutically tractable brake on fibroblast activation that promotes resolution of pulmonary fibrosis Go to The Journal of Clinical Investigation About Editors Consulting Editors For authors Publication ethics Transfers Advertising Job board Contact Current issue Past issues By specialty COVID-19 Cardiology Immunology … hellofresh price per servingWebOct 1, 2014 · Induction of KLF4 represents a novel approach to the treatment of AML and other hematologic malignancies, and LOR-253 is the only clinical stage agent to act … lake reidsville nc campground mapWebApr 10, 2024 · KLF4 contains an activation domain as well as a repression domain 21 and is therefore able to induce and suppress the transcription of different genes including molecules involved in the regulation of the immune response ( … hellofresh price per mealTakahashi and Yamanaka were the first identify KLF4 as one of four factors ( oct-3/4 + sox2 + Klf4 + c-Myc ) that are required to induce mouse embryonic and adult fibroblasts into pluripotent stem cells (iPS). This was also found to be true for adult human fibroblasts. Since 2006 up to today, the work on clinically relevant research in stem cells and stem cell induction, has increased dramatically (more than 10,000 research articles, as compared to about 60 between years 1900 … hello fresh prime rib