WebKLF4 regulates autophagy in Mtb-infected macrophages. (A, B) BMDMs or RAW264.7 (C,D) were transfected with control siRNA or Klf4 siRNA prior to infection with Mtb. WebMay 18, 2015 · SMC-specific conditional knockout of Krüppel-like factor 4 ( Klf4) resulted in reduced numbers of SMC-derived MSC- and macrophage-like cells, a marked reduction in lesion size, and increases in...
KLF4 (Kruppel-Like Factor 4)-Dependent Perivascular Plasticity ...
WebJun 4, 2015 · Macrophages are also derived from SMCs that undergo a phenotypic switch. Under the control of KLF4, the SMCs stop expressing marker proteins such as TAGLN, α-actin (ACTA2), and myosin heavy... WebApr 12, 2024 · Gain- and loss-of function study of KLF4 indicates that the DNMT1-mediated macrophage M1 activation is dependent on KLF4. Our data demonstrate a proatherogenic role for DNMT1 as a defining factor in macrophage inflammation both in vitro and in vivo. DNMT1 promotes macrophage M1 activation by suppressing KLF4 expression smoko camping ground bright
KLF4 - Wikipedia
WebOct 8, 2024 · The upregulation of macrophage makers is dependent on the transcription factor Klf4, but the exact mechanism for this activation of Klf4 has not previously been determined. 12 In this study, we demonstrate that cholesterol exposure activates all 3 pathways of the UPR and induces phenotypic switching primarily via the Perk-eIF2α-Atf4 … WebKrüppel-like factor 4 (KLF4), a zinc-finger transcription factor that suppresses inflammatory signals, is an essential regulator of macrophage polarization in adipose tissues, but the … WebJan 1, 2024 · Under the influence of lipid peroxide, KLF4-deficient macrophages are easily transformed into foam cells. Experimental cell research has shown that KLF4-deficient macrophages exhibit enhanced foam cell formation and pro-inflammatory activation in response to lipid peroxide. river tubing trips in wisconsin