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Klf4 macrophage

WebKLF4 regulates autophagy in Mtb-infected macrophages. (A, B) BMDMs or RAW264.7 (C,D) were transfected with control siRNA or Klf4 siRNA prior to infection with Mtb. WebMay 18, 2015 · SMC-specific conditional knockout of Krüppel-like factor 4 ( Klf4) resulted in reduced numbers of SMC-derived MSC- and macrophage-like cells, a marked reduction in lesion size, and increases in...

KLF4 (Kruppel-Like Factor 4)-Dependent Perivascular Plasticity ...

WebJun 4, 2015 · Macrophages are also derived from SMCs that undergo a phenotypic switch. Under the control of KLF4, the SMCs stop expressing marker proteins such as TAGLN, α-actin (ACTA2), and myosin heavy... WebApr 12, 2024 · Gain- and loss-of function study of KLF4 indicates that the DNMT1-mediated macrophage M1 activation is dependent on KLF4. Our data demonstrate a proatherogenic role for DNMT1 as a defining factor in macrophage inflammation both in vitro and in vivo. DNMT1 promotes macrophage M1 activation by suppressing KLF4 expression smoko camping ground bright https://centerstagebarre.com

KLF4 - Wikipedia

WebOct 8, 2024 · The upregulation of macrophage makers is dependent on the transcription factor Klf4, but the exact mechanism for this activation of Klf4 has not previously been determined. 12 In this study, we demonstrate that cholesterol exposure activates all 3 pathways of the UPR and induces phenotypic switching primarily via the Perk-eIF2α-Atf4 … WebKrüppel-like factor 4 (KLF4), a zinc-finger transcription factor that suppresses inflammatory signals, is an essential regulator of macrophage polarization in adipose tissues, but the … WebJan 1, 2024 · Under the influence of lipid peroxide, KLF4-deficient macrophages are easily transformed into foam cells. Experimental cell research has shown that KLF4-deficient macrophages exhibit enhanced foam cell formation and pro-inflammatory activation in response to lipid peroxide. river tubing trips in wisconsin

Cholesterol-Induced Phenotypic Modulation of Smooth Muscle …

Category:Role of Kruppel-like factor 4 in atherosclerosis

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Klf4 macrophage

Frontiers Krüppel-Like Factors in Metabolic Homeostasis and ...

WebMay 30, 2024 · The early upregulation of KLF4 in Mtb-infected macrophages, suggests that Mtb infection possibly impacts post-translational mechanisms of regulation of KLF4 as well. A post-transcriptional mechanism of upregulation of KLF4 linked to the downregulation of cellular miR-145 has been reported during infection of keratinocytes with human ...

Klf4 macrophage

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WebAug 14, 2024 · Macrophage polarization and infiltration to the tumor microenvironment (TME) is a critical determining factor for tumor progression. Macrophages are polarized … WebApr 8, 2024 · The structure of the Klf4 DNA-binding domain links to self-renewal and macrophage differentiation. Cell Mol Life Sci. 2011;68:3121–31. Article CAS PubMed Google Scholar

WebMacrophages can be classified into many different types based on their phenotype versus their functional role in the plaque. One of the classical inflammatory macrophage phenotypes is named M1, which can be induced by a combination of interferon-γ (INF-γ) and toll-like receptor 4 (TLR4) ligand lipopolysaccharide in macrophages cultured in vitro. WebJan 1, 2024 · Formononetin attenuates atherosclerosis via regulating interaction between KLF4 and SRA in apoE-/- mice - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil.

WebAug 8, 2024 · The transcription factor Klf4 was found to cooperate with Stat6 to facilitate the macrophage M2 polarization 14. Further, Klf4 was recently identified as a direct MafB transcriptional target... WebJan 25, 2024 · In young macrophages, the core molecular clock maintains healthy immune responses through KLF4. In aged macrophages, KLF4 activity diminishes despite a …

WebMar 2, 2024 · KLF4 expression was associated with immunological-related functions, infiltration of macrophages, CD8 + T cells, and other immune cells, and elevation of immune checkpoints. Higher levels of CD8 + T cells and macrophage infiltration are associated with increased KLF4 expression in HCC TMA.

WebAug 9, 2024 · Our previous study has shown that KLF4 SUMOylation plays an important role in macrophage M2 polarization. In the present study, small ubiquitin-like modifier (SUMO) … river turn woods conway nhWebOct 11, 2012 · We recently identified KLF4 as a regulator of macrophage subset specification; that is, KLF4 promotes M2 and inhibits M1 phenotype. Here, we provide evidence that KLF4-deficient macrophages exhibit enhanced proinflammatory activation and foam cell formation in response to oxidized lipids. smok official siteWebDec 10, 2024 · In contrast to PDGFR-β + cells, KLF4 reduction in α-smooth muscle actin (SMA) + cells non-cell autonomously exacerbates lung fibrosis by inducing macrophage accumulation and pro-fibrotic... smoko chats lyricsWebApr 12, 2024 · These data suggest that KLF4 is a novel regulator of macrophage polarization. TAT- and Penetratin-linked Klf4 proteins can effectively replace viral Klf4 in … river turns red in chinaWebMacrophage KLF4 expression was robustly induced in M2 macrophages and strongly reduced in M1 macrophages, observations that were recapitulated in human … smoko hand warmerWebMar 2, 2024 · KLF4 expression was associated with immunological-related functions, infiltration of macrophages, CD8 + T cells, and other immune cells, and elevation of … smoko dumpling diffuserWebIn this regard, KLF4 has been shown to cooperate with STAT6 in promoting M2 macrophage polarization; deletion of the KLF4 gene in macrophages disrupts M2 function and increases proinflammatory gene expression . Moreover, the mouse KLF4 promoter contains CREB binding sites at −269 and −232 relative to the transcription start site. smok official store