Solubility of theophylline in water
WebJan 1, 1975 · Melting Range The original synthetic literature27 reported a melting point 0 ; 264O for theophylline subsequently the melting range has been reported to be between 271° and 274O C.28 c Solubility The reported solubility of theophylline is 8.3 mg/ml in water; 12.5 mg/ml in ethanol; 11.f,Tg/ml in , Several chloroform; and sparingly soluble in ... WebMar 4, 2010 · A homogeneous phase of IL and water was obtained by heating, while cooling of the homogeneous liquid mixture produced phase separation due to the decreased solubility. Briefly, 45 μL of [HMIM] [PF 6 ] was added to about 10 mL of a water sample, and this was then heated to 70 ºC, which enabled the IL to completely dissolve in water.
Solubility of theophylline in water
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http://elephantcare.org/resources/formulary/drug-index/aminophylline-theophylline/ WebHowever, theophylline is only sparingly soluble in water and alcohol. The solubility of theophylline in water is 5.5 mg/mL, whereas in methanol and ethanol is 0.699 mg/mL and …
WebTheobromine solubility was studied in dioxane-water mixtures, a solvent system that was investigated earlier for the solubility of theophylline and caffeine. Solubilities were calculated in these polar systems by a regression method, based on an extension of the Hildebrand-Scatchard equation of regular solution theory. WebAbstract - The solubility of caffeine in water, ethyl acetate, ethanol, carbon tetrachloride, methanol, chloroform, ... It belongs to the group of chemicals known as methylxanthines, which also includes the closely related chemicals theophylline and theobromine. In its pure form, caffeine occurs as odorless, white, fleecy masses, ...
WebThe solubility of theophylline – oxalic acid co-crystal and theophylline – glutaric acid co-crystal was determined in 4:1 chlroform – methanol and in pure chloroform respectively. At equilibrium with the solid theophylline – oxalic acid co-crystal, the theophylline concentration is only 60 % of the corresponding value for the WebAug 24, 2024 · Solubility is a very important property of drugs involved in purification processes and the different pharmaceutical dosage form design stages. Otherwise, …
WebTheophylline (3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione ); anhydrous, ≥ 99%, powder;
WebThe solubility of the compound in water at 30 degrees (0.047 mg/ml) is 180-fold lower than that of theophylline (8.40 mg/ml). The complex is relatively stable in the alkaline pH range, but it hydrolyzes, releasing theophylline in acidic environments. The rate of theophylline release is pH dependent. flower arrangements for january church altarWebJun 23, 2009 · The enthalpies of solution $$ \\Updelta_{sol}^{{}} H_{m}^{{}} $$ of polymorphic forms I and II of theophylline in water at 298.15 K using the isoperibol solution calorimeter have been determined in the range of concentration (0.311–1.547) · 10−3 /mol · kg−1. The enthalpies of hydration $$ \\Updelta_{hyd}^{{}} H_{m}^{o} $$ were determined … greek life uclaWebAug 3, 2010 · The solubility of theophylline in water was modeled including hydrate formation (1:1) as well as polymorphic transitions of theophylline between the anhydrate … flower arrangements for large vasesWebAug 1, 2024 · The equilibrium solubility of caffeine and theophylline were determined in {methanol + water} binary mixtures at 298.15 K by means of the shaken flask method and … greek life uchicagoWebSolubility: Theophylline is lightly soluble in water; soluble in hot water; sparingly soluble in alcohol, chloroform, and ether. It is freely soluble in alkali hydroxide solutions and in ammonia Sweetman (2002). Ionization Constant: Value: Salt: Conditions: Reference: Comments: pKa: 8.77: monohydrate: 25° O'Neil et al (2001) greek life uciWebJul 8, 2024 · Theophylline, a typical representative of active pharmaceutical ingredients, was selected to study the characteristics of experimental and theoretical solubility measured … greek life tv showTheophylline, also known as 1,3-dimethylxanthine, is a phosphodiesterase inhibiting drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma under a variety of brand names. As a member of the xanthine family, it bears structural and pharmacological similarity to theobromine and caffeine, and is readily found in … greek life umass amherst